Introduction to popular science | aquatic products routine inspection project

REAGEN 151

Introduction to popular science | aquatic products routine inspection project



summarize

With the progress of science and technology and the development of national economy, China's aquaculture industry has been developed rapidly and has become the world's largest aquatic products producer. However, with the increase of aquaculture output and the expansion of aquaculture scale, there are a series of problems in the process of aquaculture become more and more serious. The deterioration of the breeding environment, the main breeding varieties of disease, drug abuse and other problems need to be solved.

Brief introduction and analysis of related compounds

@malachite green


brief introduction
Malachite green is a synthetic organic compound, with metallic luster green crystals, chemical name is tetramethyl diaminotriphenylmethane, it belongs to the type of triphenylmethane green dye. Malachite green is a poisonous chemical of triphenylmethane. it is not only a dye, but also a fungicide, bactericide and parasite killer. long - term overuse of malachite green can cause cancer.
Harm
Malachite green has potential carcinogenic, teratogenic and mutagenic effects.
National limits
Malachite green: not detectable.
Rongjin technology existing products
Malachite green ELISA kit, malachite green rapid detection card.

@Chloramphenicol

brief introduction
Chloramphenicol: alias levomycin, levomycin, chloramphenicol, chlortetracycline. White or yellowish green acicular, long flaky crystalline or crystalline powder. Mainly used for typhoid fever, paratyphoid fever and other salmonella and bacteroides fragilis infection.
Thiamphenicol: also known as thiamphenicol, thiamphenicol, a chloramphenicol equivalent. White crystalline powder, odorless. Can be used for treating respiratory tract, urinary tract, and intestinal tract infection caused by sensitive bacteria such as Haemophilus influenzae, Escherichia coli, and salmonella.
Florfenicol is a broad-spectrum antibiotic for animals, which has higher antibacterial activity than chloramphenicol and thiamphenicol, especially for some bacteria resistant to chloramphenicol and thiamphenicol.
Harm
Chloramphenicol is mainly harmful to inhibit bone marrow hematopoietic function, resulting in gray baby syndrome. Reversible pancytopenia in which granulocytes first decrease. Irreversible aplastic anemia.
Thiamphenicol is less harmful than chloramphenicol in application, mainly gastrointestinal reactions, toxicity to hematopoietic system is also small, can cause peripheral neuritis. Total baldness may occur in patients with renal insufficiency.
National limits
Chloramphenicol: not detectable.
Florfenicol: ( fish ) muscle + skin 1000 ppb
Thiamphenicol: ( fish ) muscle + skin 50 ppb
Rongjin technology existing products
Chloramphenicol ELISA kit, florfenicol ELISA kit, chloramphenicol rapid detection card.

@Furan tetrad


brief introduction
Nitrofurans are antibacterial drugs with nitro structure. They act on microbial enzyme system, inhibit acetyl coenzyme a, interfere with microbial carbohydrate metabolism, and thus play a bacteriostatic role. Common drugs: furazolidone, furaltadone, furacilin, nitrofurantoin; Metabolites aoz, amoz, SEM, ahd.
Furazolidone ( alias: furazolidone ) is a bactericide with a wide antibacterial spectrum, and the most sensitive bacteria are Escherichia coli, anthrax Bacillus, paratyphoid Bacillus, dysentery Bacillus, pneumonia Bacillus and typhoid Bacillus which are also sensitive to furazolidone.
Furacilin ( alias: furosemide, furosemide ) is now used clinically only as a disinfectant and antiseptic for skin and mucous membrane infections, such as suppurative otitis media, suppurative dermatitis, acute and chronic rhinitis, burns, ulcers, etc. There was little irritation to the tissue, and purulent blood had no significant effect on its disinfection.
Nitrofurantoin ( alias: furantoin, furantoin ) is a synthetic antibacterial agent with broad antibacterial spectrum, and has antibacterial effect on most gram-positive bacteria and negative bacteria, such as staphylococcus aureus, Escherichia coli, staphylococcus albus and streptococcus pyogenes. Clinically used for urinary tract infection caused by sensitive bacteria, such as pyelonephritis, urinary tract infection, cystitis and prostatitis.
Furaltadone ( alias: furaltadone ) drug antibacterial spectrum is wide, most of the gram-positive bacteria, negative bacteria have antibacterial effect, such as staphylococcus aureus, Escherichia coli, streptococcus pyogenes, etc.
Harm
Nitrofurans have a " triad" effect. " three causes" refers to carcinogenic, teratogenic and mutagenic effects. It is a direct mutagen and can cause mutation without additional exogenous activation system.
Nitrofuran metabolites are harmful to human body. Nitrofurans are rapidly metabolized in vivo, and some of the molecules of the metabolized compounds bind to cell membrane proteins to form a binding state, which can remain stable for a long time, thus delaying the elimination speed of the drugs in vivo. It is difficult to degrade furazolidone residue in protein binding state by common food processing methods ( such as barbecue, microwave processing, cooking, etc. ), but these metabolites can be released from protein under weakly acidic conditions. Therefore, when the aquatic products containing nitrofurans antibiotic residues are eaten by people, these metabolites can be released from protein under the action of gastric acid and absorbed by human body, causing serious harm.
National limits
Residual standards shall not be detected.
Rongjin technology existing products
Furacilin ELISA kit, nitrofurantoin ELISA kit, furaltadone ELISA kit, furazolidone ELISA kit, furacilin rapid detection card, nitrofurantoin rapid detection card, furaltadone rapid detection card, furazolidone rapid detection card.

@Tetracycline


brief introduction
Tetracyclines ( tetracyclines s ) are a class of broad-spectrum antibiotics produced by actinomycetes, including chlortetracycline, oxytetracycline, tetracycline and semi-synthetic derivatives of oxytetracycline, doxycycline, minocycline, etc. their structures all contain the basic skeleton of tetracene.
Harm
After long-term consumption of foods with tetracycline residues exceeding the standard or taking tetracycline antibiotics, when the dosage is too large or the use time is slightly longer. Easily cause digestive disorders in animals. Cause enteritis and diarrhea to form double infection. In addition, tetracycline drugs will directly stimulate the excessive intake of nausea, vomiting, abdominal pain, diarrhea, abdominal discomfort, loss of appetite and other symptoms. Has adverse effect on that growth of bone and teeth; Can cause damage to the liver, etc.
National limits
Oxytetracycline / chlortetracycline / tetracycline ( fish / shrimp ) meat: 100 ppb
Rongjin technology existing products
Tetracycline enzyme-linked immunosorbent assay kit, oxytetracycline enzyme-linked immunosorbent assay kit, tetracycline rapid detection card.

@Sulfa

brief introduction
Sulfonamides refer to a class of drugs with the structure of p-aminobenzene sulfonamides, which are used for the prevention and treatment of bacterial infectious diseases. There are thousands of SAS species, among which dozens are widely used and have certain curative effect. Sulfa is a kind of antibiotics commonly used in modern medicine, its variety is various, has become a large " family".
Harm
Sulfonamide can remain in animals, and have toxic and side effect such as drug resistance to human body after being eaten by human, especially sulfadimidine, which is a carcinogen. Excessive intake can cause reactions including gastrointestinal reactions such as nausea, vomiting, and diarrhea; Allergic reactions, such as rash, Stevens - John - son syndrome, phlebitis, hematochezia, allergies and angioedema; Crystalline urine, oliguria and anuria; Hemolytic anemia in patients with hematologic reactions, such as hemoglobinemia, granulocytopenia, thrombocytopenia, neonatal nuclear jaundice, and G6PD deficiency; Photosensitivity; Nervous system reactions such as peripheral neuritis, insomnia and headache.
National limits
Sulfonamides ( total ) ( all food animals ): muscle: 100 ppb
Rongjin technology existing products
Sulfanilamide ELISA kit, sulfadimidine ELISA kit, sulfanilamide rapid detection card.

@Quinolones


brief introduction
Quinolones, also known as picolinic acids or picolinic acids, are synthetic antibacterial agents containing 4 - quinolones. Quinolones target DNA of bacteria, interfere with DNA gyrase, further cause irreversible damage to bacterial DNA, achieve antibacterial effect. Norfloxacin was synthesized in 1979, followed by a series of new fluoroquinolones, commonly known as fluoroquinolones. Quinolones are divided into four generations, clinical application is more for the third generation, commonly used drugs are norfloxacin, ofloxacin, ciprofloxacin, fleroxacin, etc.
Harm
Long - term human consumption of animal food containing low concentrations of quinolones, Chinese patent medicine health food, easy to induce drug resistance transfer, thus affecting the clinical efficacy of such drugs.
National limits
On September 1, 2015, the Ministry of agriculture issued a decision to stop the use of lomefloxacin, pefloxacin, ofloxacin and norfloxacin in food animals. Since December 31, 2016, the use of lomefloxacin, pefloxacin, ofloxacin, norfloxacin four veterinary drugs in food animals.
Enrofloxacin ( other animals ): muscle: 100 ppb
Flumequine ( fish ): muscle + skin: 500 ppb
Dapfloxacin ( other animals ): muscle: 100 ppb
Sarafloxacin ( fish ): muscle + skin: 30 ppb
Difloxacin ( other animals ): muscle: 300 ppb
Rongjin technology existing products
Quinolone ELISA kit, enrofloxacin ELISA kit, ciprofloxacin ELISA kit, ofloxacin ELISA kit, quinolone rapid detection card.



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